Dr Opeyemi Stella Ademowo


Lecturer

Stella wearing a pink top, smiling.

Subject

Biomedical Health and Human Biology

College

College of Life and Natural Sciences

Department

School of Human Sciences

Research centre

Human Sciences Research Centre

Email

s.ademowo@derby.ac.uk

About

I am a lecturer in Biomedical Science. My research focus is on biomarkers of ageing and I am involved in research supervision.

Teaching responsibilities

I teach on cell and molecular biology related modules within the Biomedical Health and Human Biology discipline.

Research interests

I am interested in translational research, focusing on patient benefits and basic science that includes an understanding of disease mechanism and prognosis with potential for discovery and development of biomarkers and therapeutic targets. My previous work includes the use of mass spectrometry to develop protein biomarkers to predict response to therapy in inflammatory arthritis, development of oxidised phospholipid markers in Alzheimer’s disease and chronic kidney disease, investigation on the effects of antioxidants on oxidative stress and the effects of endoplasmic reticulum shaping proteins on morphoregulation in neuronal cells.

I have also monitored oxidative stress and mitochondrial function/dysfunction in age-related diseases. At the moment, I seek to understand cellular senescence in vitro and vivo to inform future strategies for clearing senescence; in order to promote healthy ageing and also to manage the economic impact of the growing ageing population. I use cell/molecular Biology, Biochemistry, Lipidomics, Proteomics, and mitochondria Biology techniques in my research.

Membership of professional bodies

Qualifications

Recent conferences

Experience in industry

I have experience in Pharmaceutical industry as a trainee analyst in the quality control department, EMZOR pharmaceuticals, Lagos, Nigeria during my undergraduate degree program. I have also worked with interdisciplinary and multidisciplinary team which includes collaborations with Abbott Pharmaceuticals, Rheumatology departments Amsterdam Medical centre, Netherlands and St Vincents University Hospital, Dublin Ireland, during my PhD. In addition to these, I collaborated with Macuvison Europe Ltd. UK and Waterford Medical Centre, Ireland during my first postdoctoral training.

International experience

I have engaged in projects with different academic staff from overseas institutions, including the University of Amsterdam Netherlands, University of Dusseldorf, Germany, University of Porto, Portugal, University College Dublin, and Dublin City University, Ireland. I successfully transferred an HPLC method for carotenoid analysis which I learned from The Biochemistry Department, University of Dusseldorf to Aston University in order to investigate the effect of carotenoid supplementation on Alzheimer’s disease and the method was published. I have presented my work in a number of national and international conferences with awards in a couple; with the latest award obtained at the keystone symposia in California, USA 2017 based on merit.  

Recent publications

Irundika H.K. Dias, Ivana Milic, Christian Heiss, Opeyemi S. Ademowo, Maria Cristina Polidori, Andrew Devitt, and Helen R. Griffiths. Inflammation, Lipid (Per)oxidation, and Redox Regulation [published online ahead of print, 2020 Feb 28]. Antioxid Redox Signal. 2020;10.1089/ars.2020.8022. doi:10.1089/ars.2020.8022.

Ademowo OS, Dias IHK, Diaz-Sanchez L, Sanchez-Aranguren L, Stahl W, Griffiths HR. Partial Mitigation of Oxidized Phospholipid-Mediated Mitochondrial Dysfunction in Neuronal Cells by Oxocarotenoids [published online ahead of print, 2020 Jan 20]. J Alzheimers Dis. 2020;10.3233/JAD-190923. doi:10.3233/JAD-190923.

Opeyemi Stella Ademowo, Praveen Sharma, Paul Cockwell, Ana Reis, Iain L. Chapple, Helen R. Griffiths, Irundika H.K. Dias. Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity, Free Radical Biology and Medicine, Volume 146, 2020, Pages 130-138, doi: 10.1016/j.freeradbiomed.2019.10.012. 

O.S. Ademowo, H.K.I. Dias, C. Pararasa, H.R Griffiths. Nutritional hormesis in a modern environment In: The science of hormesis in health and longevity (Chapter 6) Editors: Suresh I. S. Rattan and Marios Kyriazis. Academic Press, 2019, Pages 75-86, ISBN 9780128142530, doi.org/10.1016/B978-0-12-814253-0.00006-1.

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P.,… Ademowo, O.S., … Daiber, A., “European Contribution to the study of ROS: A Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS),” Redox Biol., vol. 13, pp. 94–162, Oct. 2017. DOI: 10.1016/j.redox.2017.05.007.

Ademowo, O.S., Dias, H. K. I., Burton, D. G. A., and Griffiths, H. R., “Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?,” Biogerontology, vol. 18, no. 6, pp. 859–879, Dec. 2017 doi.org/10.1007/s10522-017-9710-z 

Ademowo, O.S., Dias H.K.I., Milic, I., Devitt, A., Moran, R., Mulcahy, R., … Griffiths, H. R., “Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients,” Free Radic. Biol. Med., vol. 108, pp. 77–85, Jul. 2017. doi: 10.1016/j.freeradbiomed.2017.03.008.

Ademowo, O. S., Hernandez, B., Collins, E., Rooney, C., Fearon, U., van Kuijk, A. W., … Pennington, S. R., “Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis.,” Ann. Rheum. Dis., vol. 75, no. 1, pp. 234–41, Jan. 2016. doi:10.1136/annrheumdis-2014-205417.

L. Staunton, T. Clancy, C. Tonry, O.S. Ademowo, M. Dharsee, B.H. Hernandez, K. Evans, R.W. Watson, A. Parnell and S.R. Pennington (2014). Protein Quantification by MRM for Biomarker Validation In Quantitative Proteomics Chpt13 pp279-315. Publisher: Royal Society of Chemistry. Claire Eyers and Simon Gaskell (Ed.). ISBN:978-1-84973-808-8.

Ademowo OS, Staunton L, FitzGerald O, Pennington SR.(2013) Biomarkers of Inflammatory Arthritis and Proteomics. In: Spaska Angelova Stanilova, ed. Genes and Autoimmunity- Intracellular Signalling and Microbiome Contribution. INTECH 2013 pp237–67. doi:http://dx.doi.org/10.5772/54218.