Staff profile

Dr Laurice Fretwell


Course Director in Human Sciences

Laurice Fretwell in a teaching room

College

College of Life and Natural Sciences

Department

School of Human Sciences

Research centre

Human Sciences Research Centre

Campus

Kedleston Road, Derby Campus

Email

L.Fretwell@derby.ac.uk

About

As Course Director for the School of Human Sciences, I work across all disciplines to enhance teaching, learning and the student experience.    

My background is in Physiology and Pharmacology and I continue to teach and research in these areas.

Teaching responsibilities

I am module leader for our Industrial Placement Year modules, and teach on different modules on Human Biology and Biomedical Health.  I also supervise undergraduate and postgraduate student research projects.

Professional interests

I lead on the enhancement and embedding of employaility activity across the School of Human Sciences.  As part of this, I am always interested to speak to employers about how we can work together to provide work experience or volunteering for our students, and ensure that we produce highly-skilled workplace-ready graduates.  

Research interests

After graduating from BSc (Hons.) Physiology and Pharmacology, I completed my PhD at Nottingham Trent University into the role of BKCa channels in adenosine-receptor mediated cytoprotection (using H9c2 cells and ventricle strips to model hypoxia-reoxygenation injury).  

I was then awarded a Career Development Fellowship in Cardiovascular Pharmacology & Drug Discovery at the University of Nottingham, where I monitored regional haemodynamic responses in vivo and developed skills in pressure myography.  

Since then, I have supervised PhD and MRes students and am keen to pursue research and collaborate in the following areas:

Membership of professional bodies

Fellow of the Higher Education Authority

Qualifications

BSc (Hons.) Physiology and Pharmacology, Nottingham Trent University

PhD: The role of BKCa channels in adenosine receptor-mediated cytoprotection, Nottingham Trent University

Recent publications

Driskel M, Horsley A, Fretwell LClayton N, Al-Aloul M. (2019) Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome. ERJ Open Res. 5: 00164-2019.

Carter JJ, Fretwell LV, Woolard J. (2017) Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats. FASEB J. 31(3):1193-1203. 

Fretwell LV, Woolard J. (2013) Cardiovascular responses to retigabine in conscious rats--under normotensive and hypertensive conditions. Br J Pharmacol. 169(6):1279-89. 

Baker JG, Kemp P, March J, Fretwell L, Hill SJ, Gardiner SM. (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 25(12):4486-97. 

Fretwell L, Dickenson JM. (2011) Role of large-conductance Ca²+-activated K+ channels in adenosine A₁ receptor-mediated pharmacological postconditioning in H9c2 cells. Can J Physiol Pharmacol. 89(1):24-30. 

Fretwell L, Dickenson JM. (2009) Role of large-conductance Ca(2+) -activated potassium channels in adenosine A(1) receptor-mediated pharmacological preconditioning in H9c2 cells. Eur J Pharmacol. 618(1-3):37-44.