Staff profile

Dr Elizabeth Marsh


Lecturer in Cellular and Molecular Biology

Elizabeth Marsh working in Forensics lab

Subject

Biology and Zoology, Biomedical Health and Human Biology

College

College of Life and Natural Sciences

Department

School of Human Sciences

Campus

Kedleston Road, Derby Campus

Email

e.marsh@derby.ac.uk

About

I obtained my BSc and PhD from the Department of Biological Sciences at the University of Birmingham before embarking on postdoctoral research dissecting host-pathogen interactions in epithelial cells at the University of Birmingham (Cancer Sciences) and then at the University of Sheffield (Infection, Immunity and Cardiovascular Disease). I was appointed as Lecturer in Molecular and Cellular Biology at the University of Derby in 2017.

Teaching responsibilities

I teach on and lead modules across our Biosciences programmes including Concepts of Health and Disease, Anatomy and Physiology, Chemistry of Life, Microbiology, Oncology and Immunology, Biomedical Professional Practice, Genetics, Molecular Biology, and Independent Study. I am also the Level 4 (first year) lead for our Biomedical Health and Human Biology programmes.

Research interests

My research interests are rooted in host-pathogen interactions and innate immunity. I utilise a basic science approach to probe the host response to pathogenic infection in order to identify and explore the potential of targeting specific interactions for their therapeutic potential in infectious disease. 

My PhD studies utilised molecular and survival analyses to describe immunological gene ‘trade-offs’ during infection with the bacteria Salmonella Typhimurium and fungal pathogen Cryptococcus neoformans in the model host Caenorhabditis elegans. During my first post-doctoral research in the CRUK (Cancer Research UK) Institute for Cancer Sciences at Birmingham, I utilised an organotypic raft model to dissect the interaction between the human papillomavirus (HPV) oncoprotein E6 and host PDZ proteins in cervical cancer.

I moved to the University of Sheffield in 2014 to continue my interest in virus-host interactions. I developed a complementary approach of epithelial cell and murine models to describe the role of a TLR3 effector, Pellino-1, in controlling the inflammatory response to respiratory viruses (rhinovirus and influenza A). 

I now lead a number of projects investigating the natural history and epidemiology of HPV in head and neck cancer.

Membership of professional bodies

Qualifications

Recent conferences

Experience in industry

Research posts

International experience

I like to work collaboratively and have worked in the labs of Professor Fred Ausubel and Dr Javier Irazoqui at Harvard Medical School, Dr Lawrence Banks at the ICGEB, Trieste, and Professor Paul Moynagh at NUI Maynooth.

In the media

July 2018 - My response to the Government's announcement for gender-neutral vaccination was covered by both The Independent and the Huffington Post.

Recent publications

Manley, GCA., Stokes, CA., Marsh, E.K., Sabroe, I., Parker L.C. (2018) DUSP10 negatively regulates the inflammatory response to rhinovirus through IL-1β signalling. Journal of Virology (accepted)

Marsh E.K., Delury, C.P., Davies, N.J., Weston, C.J., Miah, M.A.L., Banks, L., Parish, J.L., Higgs, M.R., Roberts, S. Mitotic Control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. (2017) Oncotarget 8:19491-19506 DOI: 10.18632/oncotarget.14469

Roberts J.A., Miguel-Escalada I., Slovik K.J., Walsh K.T., Yavor Hadzhiev, Sanges R., Stupka E., Marsh E.K., Balciunene J., Balciunas D., Müller F. (2014) Targeted transgene integration overcomes variability of position effects in zebrafish.  Development 141(3): 715-24

Delury C.P.1, Marsh E.K.1, James C.D., Boon S.S., Banks L., Knight G.L., Roberts S. (2013) The role of protein kinase A regulation of the E6 PDZ-binding domain during the differentiation-dependent life cycle of human papillomavirus type 18.  Journal of Virology 87(17): 9463-72  1Joint first author

Roberts S., Delury C., Marsh E. (2012) The PDZ protein discs-large (DLG): the ‘Jekyll and Hyde’ of the epithelial polarity proteins. FEBS Journal 279(19): 3549-58

Marsh E. K., May, R. C. (2012) Caenorhabditis elegans: a model organism for investigating immunity. Applied Environmental Microbiology 78(7): 2075-81

Marsh, E.K., van den Berg, M.C.W., May, R.C. (2011) A two-gene balance regulates Salmonella Typhimurium tolerance in the nematode Caenorhabditis elegans. PLoS One 6(3): e16839

Blog Posts

Dr Elizabeth Marsh, Lecturer in Cellular and Molecular Biology at the University of Derby, explains why allowing boys to have the HPV jab is long overdue.