About

I am an Experienced Scientist developing diverse therapeutics and diagnostics with focus on Cancers (Breast/Ovarian/Lymphatic). My expertise is 'Drug discovery' and 'Microscopy'. I teach Biomedical science and Chemistry modules. 

Teaching responsibilities

• Human Physiology and Disease (5BY511)
• Clinical Immunology (5BY544)
• Principles of Chemistry (3FO503)
• Chemistry of Life (4FO408)

Professional interests

• Drug discovery and Diagnostics design and development 
• Pharmaceuticals
• Cancer Research 
• Multimodal Imaging

Research interests

• Drug discovery 
• Molecular Diagnostics
• Breast Cancer 
• Lymphatic Cancer
• Nanomedicine
• Microscopy

Membership of professional bodies

• AMRSC - Royal Society 
• FHEA - Advance HE

Qualifications

• PhD Chemical Biology (University of Sheffield)
• Postdoctoral Research Scientist, CRUK, Cancer Theragnostic discovery and development (University of Oxford)
• Post graduate certificate in Teaching and Academic practice (University of Derby)

Recent conferences

• RSC photochemistry meeting, Newcastle, UK
• 11^th Nucleic acids forum, RSC Burlington house, London
• DYME (Dalton trans. conference), Leeds, U.K
• International conference on Innovation in Pedagogy, Oxford, UK

Experience in industry

• Sun Pharmaceuticals R&D Inc., India
• Central Leather Research Institute (CLRI)., India
• Central Salt and Marine Research Institute (CSMRI)., India

International experience

• Visiting Scientist - Dublin City University, Republic of Ireland
• Visiting Scientist - Central Salt and Marine Research Institute, India

Additional interests and activities

• Editor (Special Issue): Advances in Targeted delivery of Nanomedicines' - Molecules (MDPI) 
• Topic Editor - Biosensors (Switzerland)
• Reviewer - Royal Society Journals
• Visiting Researcher - Rutherford Appleton Research Laboratories (STFC), Oxford

In the media

• Development of novel DNA binding Super resolution probe which can capture cancer signalling processes in detail 
• New super-resolution probe captures cells in unprecedented detail

Recent publications

• Asha Guraka, Sreejesh Sreedharan, Ramesh Arasaradnam, Gyan Tripathi, Ali Kermanizadeh The role of gut microbiome in the development and progression of type 2 diabetes and liver disease. Nutr. Rev., 2024 (DOI: 10.1093/nutrit/nuae172

• Anik Kumar Dey, Subhadeep Das, Sharon Mary Jose, Sreejesh Sreedharan, Noufal Kandoth, Surajit Barman, Abhijit Patra, Amitava Das, Sumit Kumar. Pramanik Surface functionalized perovskite nanocrystals: a design strategy for organelle-specific fluorescence lifetime multiplexing. Chemical Science, 2024 (DOI: 10.1039/D4SC01447B))

• Hiwa Saeed, Paul J Jarman, Sreejesh Sreedharan, Rachel Mowll, Alexander J Auty, Adrien AP Chauvet, Carl GW Smythe, Jorge Bernardino de la Serna, Jim A Thomas. From Chemotherapy to Phototherapy – Changing the Therapeutic action of a Metallo-intercalating Ru-Re Luminescent system by switching its sub-cellular location. Chemistry: A European Journal, 2023 (DOI: 10.1002/chem.202300617)

• Sreejesh Sreedharan, Georgios Zouganelis, Samantha J Drake, Gyanendra Tripathi, Ali Kermanizadeh Nanomaterial-induce toxicity in pathophysiological models representative of individuals with pre-existing health conditions. Journal of Toxicology and Environmental health: Part B, 26, 2023 (DOI: 10.1080/10937404.2022.2153456) 

• Sumit Kumar Pramanik, Sreejesh Sreedharan, Rajeshwari Tiwari, Noufal Kandoth, Samit Chatopadhyay, Amitava Das, James A. Thomas. Nanoparticles for super-resolution microscopy: Intracellular delivery and molecular targeting. Chemical Society Reviews, 2022, 15, 9882-9916 (DOI: 10.1039/D1CS00605C)

• Sheik Saleem Pasha, Amrita Banerjee, Sreejesh Sreedharan, Soumendra Singh, Noufal Kandoth, Katherine A Vallis, Samir Kumar Pal, Sumit Kumar Pramanik, Amitava Das. An Ultrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria. Inorganic Chemistry, 2022, 61, 13115-13124 (DOI: 10.1021/acs.inorgchem.2c01761)

• Fabian Dröge, Stuart A. Archer, Felicity Noakes, Sreejesh Sreedharan, Ahtasham Raza, Craig C. Robertson, Sheila MacNeil, John W. Haycock, Anthony J.H.M. Meijer, Jorge Bernardino de la Serna, Benjamin Dietzek and Jim A. Thomas A NIR nanoscopy probe for nuclear DNA. Journal of the American Chemical Society, 2021, 143, 20442-20453 (DOI: 10.1021/jacs.1c10325)

• Rajeshwari Tiwari^#, Prashant S. Shinde^#, Sreejesh Sreedharan^#, Anik Dey, Katherine A. Vallis, Santosh B. Mhaske, Sumit Kumar Pramanik and Amitava Das Photoactivable prodrug for simultaneous release of mertansine, and CO along with a BODIPY Derivative as a luminescent marker in mitochondria: A proof of concept for NIR Image-guided cancer therapy.  Chemical Science, 2021, 12, 2667-2673 (DOI: 10.1039/D0SC06270G)

• Sreejesh Sreedharan^#, Rajeshwari Tiwari^#, Deepak Tyde, Stephen Aderinto, Sumit Kumar Pramanik, Amitava Das, James A. Thomas. Nanocarriers used as probes for super-resolution microscopy. Materials Chemistry Frontiers, 2021, 5, 1268-1282 (DOI: 10.1039/D0QM00684J)

• Harwinder Singh, Sreejesh Sreedharan, Esteban Oyarzabal, Tufan Singha Mahapatra, Nicola Green, Yen-Yu Ian Shih, Manasmita Das, Jim. A. Thomas, Sumit Kumar Pramanik, Amitava Das. Mitochondriotropic lanthanide nanorods: Implications for multimodal imaging. Chemical Communications, 2020, 56, 7945-7948 (DOI: 10.1039/D0CC02698K)

• Hiwa Saeed, Sreejesh Sreedharan, Jim A Thomas. Photoactive metal complexes as cell probes, therapeutics and theranostics. Chemical Communications, 2020, 56, 1464-1480 (DOI: 10.1039/C9CC09312E)

• Hiwa Saeed, Sreejesh Sreedharan, Paul Jarman, Stuart Archer, Simon Foxton, Alexander Auty, Dimitri Chekulaev, Theo keane, Anthony Meijer, Julia Weinstein, Carl Smythe, Jorge Bernardino de la Serna, Jim A Thomas. The right link to theranostics: the photophysical and biological properties of dinuclear RuII-ReI dppz complexes depend on their tether ligand. Journal of the American Chemical Society, 2020, 142, 1101-1111

• Harwinder Singh^#, Sreejesh Sreedharan^#, Karishma Tiwari, Nicola H Green, Carl G Smythe, Sumit kumar Pramanik, Jim A Thomas and Amitava Das. Two photon excitable graphene quantum dots for structured illumination microscopy and imaging application: lysosome specificity and tissue-dependent imaging. Chemical Communications, 2019, 55, 521-524 (DOI: 10.1039/C8CC08610A)

• Harwinder Singh, Sreejesh Sreedharan, Rajeshwari Tiwari, Christa Walther, Carl G Smythe, Sumit Kumar Pramanik, Jim A Thomas, and Amitava Das. A fluorescent chemo-dosimeter for organelle-specific imaging of nucleoside polyphosphate dynamics in living Cells. Crystal Growth & Design, 2018, 18, 7199-7206 (DOI: 10.1021/acs.cgd.8b01409)

• Sumit Kumar Pramanik^#, Sreejesh Sreedharan^#, Harwinder Singh, Mohsina Khan, Karishma Tiwari, Anjali Shiras, Carl G Smythe, Jim A Thomas, Amitava Das. Mitochondria targeting non-isocyanate-based polyurethane nano-capsules for enzyme-triggered drug release. Bioconjugate chemistry, 2018, 29, 3532-3543 (DOI: 10.1021/acs.bioconjchem.8b00460)

• Anila H A, Sreejesh Sreedharan, Firoj Ali, Carl G Smythe, Jim A Thomas, Amitava Das. Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging. Chemical Communications, 2018, 54, 3735-3738 (DOI: 10.1039/C8CC01332B)

• Sreejesh Sreedharan^#, Alessandro Sinopoli^#, Paul. J. Jarman, Darren Robinson, Christopher Clemmet, Paul A Scattergood, Craig R Rice, Carl G Smythe, James A Thomas, Paul I P Elliott. Mitochondria-localizing DNA binding biscyclometalated phenyltriazole iridium (III) dipyridophenazene complexes: syntheses and cellular imaging properties. Dalton Transactions, 2018, 47, 4931-4940 (DOI: 10.1039/C8DT00046H)

• Firoj Ali^#, Sunil Aute^#, Sreejesh Sreedharan^#, Anila H A, Hiwa K Saeed, Carl G Smythe, Jim A Thomas, Amitava Das. A luminescent probe for super-resolution imaging of endogenous HOCl in multiple cellular compartments in macrophages. Chemical Communications, 2018, 54, 1849-1852 (DOI: 10.1039/C7CC09433G)

• Sumit Kumar Pramanik^#, Sreejesh Sreedharan^#, Harwinder Singh, Nicola H Green, Carl G Smythe, Jim A Thomas, Amitava Das. Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles. Chemical Communications, 2017, 53, 12672-12675 (DOI: 10.1039/C7CC08185E)

• Firoj Ali, Sreejesh Sreedharan, Anila H A, Hiwa K Saeed, Carl G Smythe, Jim A Thomas, Amitava Das. A super-resolution probe to monitor HNO levels in the endoplasmic reticulum of RAW cells. Analytical Chemistry, 2017, 89, 12087–12093 (DOI: 10.1021/acs.analchem.7b02567)

• Hiwa K Saeed, Paul J Jarman, Stuart Archer, Sreejesh Sreedharan, Ibrahim Q Saeed, Luke K Mckenzie, Julia A Weinstein, Niklaas J Buurma, Carl G Smythe, Jim A Thomas. Homo and heteroleptic phototoxic dinuclear metallo-intercalators based on Ru^II(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie International Edition, 2017, 56, 12628-12633 (DOI: 10.1002/anie.201707350)

• Sreejesh Sreedharan, Martin R Gill, Esther Garcia, Hiwa K Saeed, Darren Robinson, Aisling Byrne, Ashley J Cadby, Tia E Keyes, Carl G Smythe, Patrina Pellett, Jorge Bernardino de la Serna, Jim A Thomas. Multi model super-resolution microscopy using a transition metal complex probe provides unprecedented capabilities for imaging both nuclear chromatin and mitochondria.  Journal of the American Chemical Society, 2017, 139, 15907–15913 (DOI: 10.1021/jacs.7b08772)

• Lei Song, Yuan Guo, Deborah Roebuck, Chun Chen, Min Yang, Zhongqiang Yang, Sreejesh Sreedharan, Caroline Glover, Jim A Thomas, Dongsheng Liu, Shengrong Guo, Rongjun Chen, Dejian Zhou. Terminal PEGylated DNA–Gold nanoparticle conjugates offering high resistance to nuclease degradation and efficient intracellular delivery of DNA binding Agents. ACS Applied Materials & Interfaces, 2015, 7, 18707–18716 (DOI: 10.1021/acsami.5b05228)